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Short term response of insulin, glucose, growth hormone and corticosterone to acute vibration in rats.Study carried out to obtain some notion of the initial phasing and interactive effects among some hormones known to be responsive to vibration stress. Sprague-Dawley derived rats were exposed to the acute effects of confinement and confinement with lateral (plus or minus G sub y) vibration. The coincident monitoring of glucose, insulin, growth hormone, and corticosterone plasma levels, during and immediately subsequent to exposure to brief low level vibration, exhibits the effects of inhibition of insulin release by epinephrine. The ability of insulin (IRI) to return rapidly to basal levels, from appreciably depressed levels during vibration, in the face of elevated levels of glucose is also shown. Corticosterone responds with almost equal rapidity, but in opposite phase to the IRI. The immuno-assayable growth hormone (IGH) dropped from a basal level of 32 ng/ml to 7.3 ng/ml immediately subsequent to vibration and remained at essentially that level throughout the experiment (60 min). Whether these levels represent a real fall in the rat or whether they merely follow the immuno-logically deficient form is still in question.
Document ID
19720027623
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Dolkas, C. B.
Leon, H. A.
Chackerian, M.
(NASA Ames Research Center Moffett Field, Calif., United States)
Date Acquired
August 6, 2013
Publication Date
July 1, 1971
Publication Information
Publication: Aerospace Medicine
Volume: 42
Subject Category
Biosciences
Accession Number
72A11289
Distribution Limits
Public
Copyright
Other

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