The effect of imidazole, cyanamide, and polyornithine on the condensation of nucleotides in aqueous systems.Development of two models for the condensation of nucleotides under possibly prebiotic conditions. In the first of these models this type of reaction is promoted by the presence of imidazole and substituted imidazole compounds. The second model involves the condensation of mononucleotides with cyanamide in the presence and absence of a prototemplate such as polyornithine. A tentative mechanism for the role of imidazole catalysis in phosphodiester bond formation between adjacent TMP molecules is suggested.
Document ID
19720031100
Acquisition Source
Legacy CDMS
Document Type
Conference Proceedings
Authors
Ibanez, J.
Kimball, A. P.
Oro, J. (Houston, University Houston, Tex., United States)
Date Acquired
August 6, 2013
Publication Date
January 1, 1971
Subject Category
Chemistry
Meeting Information
Meeting: Chemical evolution and the origin of life; Third International Conference