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Effect of circadian rhythm on CNS oxygen toxicity.The circadian rhythm in susceptibility to oxygen toxicity seizures was investigated by using six groups of 20 male Sprague-Dawley rats (101-196 gm.). The animals were given standard chow, exposed to standard diurnal conditions of light (0700-1900 hr) and dark (1900-0700 hr), and fasted for 15-16 hr prior to exposure to hyperbaric oxygen. The animals were placed in a previously oxygen flushed chamber and raised to 60 psi (gauge) oxygen at a rate of 3 psi/min. Time of exposure started with attainment of 60 psi. End point was first convulsion. The animals' weights were equally distributed within the groups, and the groups were defined by hour of exposure. Time of exposure in minutes prior to seizure was significantly longer in those exposed at 0700-0800 hr and 1000-1100 hr than in four other groups. There was no relationship between animals' weights and time of exposure to seizures. All R values were negative, and the highest R value was -035. These data suggest a definite circadian rhythm in susceptibility to oxygen toxicity seizures.
Document ID
19720031201
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Hof, D. G.
Dexter, J. D.
Mengel, C. E.
(Missouri, University Columbia, Mo., United States)
Date Acquired
August 6, 2013
Publication Date
December 1, 1971
Publication Information
Publication: Aerospace Medicine
Volume: 42
Subject Category
Biosciences
Accession Number
72A14867
Funding Number(s)
CONTRACT_GRANT: NAS9-9417
CONTRACT_GRANT: NIH-CA-11447
CONTRACT_GRANT: N00014-67-A-0003
CONTRACT_GRANT: NAS9-9209
Distribution Limits
Public
Copyright
Other

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