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Action of acetylstrophanthidin on experimental myocardial infarction.An experimental animal model with acute myocardial infarction of a size insufficient to produce profound heart failure or shock was used to study the effects of acute infarction on digitalis tolerance and the hemodynamic changes produced by moderate and large doses of acetylstrophanthidin. With acute myocardial infarction, digitalis toxic arrhythmias could be precipitated with significantly lower doses of digitalis than in animals without myocardial infarction. There was no precise correlation between the size of infarction and the toxic dose of glycoside. Coronary artery ligation produced a stable but relatively depressed circulatory state, as evidenced by lowered cardiac output and stroke volume and elevated systemic vascular resistance and left atrial mean pressure. When digitalis was infused, the following significant changes were observed at nontoxic doses: (1) elevation of aortic and left ventricular pressures; (2) further decline in cardiac output; and (3) decreased left atrial mean pressure.
Document ID
19720037416
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Nola, G. T.
Pope, S. E.
Harrison, D. C.
(Stanford University Palo Alto, Calif., United States)
Date Acquired
August 6, 2013
Publication Date
February 1, 1972
Publication Information
Publication: American Journal of Physiology
Volume: 222
Subject Category
Biosciences
Accession Number
72A21082
Funding Number(s)
CONTRACT_GRANT: NIH-HE-05866
CONTRACT_GRANT: NGR-05-020-305
CONTRACT_GRANT: NIH-5SO-1FR-05353-08
CONTRACT_GRANT: NIH-HE-09058
CONTRACT_GRANT: NIH-HE-5709
Distribution Limits
Public
Copyright
Other

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