Role of mineralocorticoids in the natriuresis of water immersion in man.

In an attempt to assess the quantitative contribution of aldosterone suppression to the natriuresis of water immersion, renal sodium handling in normal male subjects undergoing water immersion was examined before and after administration of exogenous mineralocorticoid. The study demonstrated that the administration of a potent mineralocorticoid in pharmacological doses failed to abolish the natriuresis of water immersion.