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Glycolytic intermediates and adenosine phosphates in rat liver at high altitude /3,800 m/.Liver tissue obtained from adult rats exposed to 3800 m altitude for intervals ranging from 1.5 hr to 63 days was examined by enzymatic analysis. During the first 3 hr of exposure, an immediate decrease in rephosphorylation of high-energy phosphates led to reduced glycogenesis and eventual pileup of AMP, pyruvate, fructose 1,6-diphosphate, glucose 6-phosphate, and glucose. This was accompanied by a reduction of pentose phosphate pathway activity. After 3 to 6 hr, a secondary adjustment of substrate concentrations occurred along with the apparent facilitation of phosphofructokinase. This secondary adjustment appears to increase anaerobic production of ATP and represents a significant intracellular contribution to the acclimatization process at high altitude.
Document ID
19730054800
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Cipriano, L. F.
Pace, N.
(California, University Berkeley, Calif., United States)
Date Acquired
August 7, 2013
Publication Date
August 1, 1973
Publication Information
Publication: American Journal of Physiology
Volume: 225
Subject Category
Biosciences
Accession Number
73A39602
Funding Number(s)
CONTRACT_GRANT: NGL-05-003-024
Distribution Limits
Public
Copyright
Other

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