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Serotonin and pituitary-adrenal functionAn investigation is conducted to evaluate the response of the pituitary-adrenal system to a stress stimulus in the rat. In the investigation brain serotonin synthesis was inhibited with p-chlorophenylalanine. In other tests the concentration of serotonin was enhanced with precursors such as tryptophan or 5-hydroxytryptophan. On the basis of the results obtained in the study it is speculated that in some disease states there is a defect in serotonergic neuronal processes which impairs pituitary-adrenal feedback mechanisms.
Document ID
19740044240
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Berger, P. A.
Barchas, J. D.
(Stanford University Stanford, Calif., United States)
Vernikos-Danellis, J.
(NASA Ames Research Center Human Studies Branch, Moffett Field, Calif., United States)
Date Acquired
August 7, 2013
Publication Date
March 29, 1974
Publication Information
Publication: Nature
Volume: 248
Subject Category
Biosciences
Accession Number
74A26990
Distribution Limits
Public
Copyright
Other

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