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Brain serotonin and pituitary-adrenal functionsIt had been concluded by Scapagnini et al. (1971) that brain serotonin (5-HT) was involved in the regulation of the diurnal rhythm of the pituitary-adrenal system but not in the stress response. A study was conducted to investigate these findings further by evaluating the effects of altering brain 5-HT levels on the daily fluctuation of plasma corticosterone and on the response of the pituitary-adrenal system to a stressful or noxious stimulus in the rat. In a number of experiments brain 5-HT synthesis was inhibited with parachlorophenylalanine. In other tests it was tried to raise the level of brain 5-HT with precursors.
Document ID
19740050649
Acquisition Source
Legacy CDMS
Document Type
Conference Proceedings
Authors
Vernikos-Danellis, J.
Berger, P.
Barchas, J. D.
(NASA Ames Research Center Biomedical Research Div., Moffett Field; Stanford University, Stanford, Calif., United States)
Date Acquired
August 7, 2013
Publication Date
January 1, 1973
Subject Category
Biosciences
Meeting Information
Meeting: International Symposium of the Drug effects on neuroendocrine regulation
Location: Snowmass-at-Aspen, CO
Start Date: July 17, 1972
End Date: July 19, 1972
Accession Number
74A33399
Distribution Limits
Public
Copyright
Other

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