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Three-dimensional tertiary structure of yeast phenylalanine transfer RNAResults of an analysis and interpretation of a 3-A electron density map of yeast phenylalanine transfer RNA. Some earlier detailed assignments of nucleotide residues to electron density peaks are found to be in error, even though the overall tracing of the backbone conformation of yeast phenylalanine transfer RNA was generally correct. A new, more comprehensive interpretation is made which makes it possible to define the tertiary interactions in the molecule. The new interpretation makes it possible to visualize a number of tertiary interactions which not only explain the structural role of most of the bases which are constant in transfer RNAs, but also makes it possible to understand in a direct and simple fashion the chemical modification data on transfer RNA. In addition, this pattern of tertiary interactions provides a basis for understanding the general three-dimensional folding of all transfer RNA molecules.
Document ID
19740054400
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Kim, S. H.
Sussman, J. L.
(Duke University Durham, N.C., United States)
Suddath, F. L.
Quigley, G. J.
Mcpherson, A.
Wang, A. H. J.
Seeman, N. C.
Rich, A.
(MIT Cambridge, Mass., United States)
Date Acquired
August 7, 2013
Publication Date
August 2, 1974
Publication Information
Publication: Science
Volume: 185
Subject Category
Chemistry
Accession Number
74A37150
Funding Number(s)
CONTRACT_GRANT: NSF GB-30688
CONTRACT_GRANT: NIH-CA-04186
CONTRACT_GRANT: NIH-CA-15802
CONTRACT_GRANT: NSF GB-40814
CONTRACT_GRANT: NIH-CA-14015
Distribution Limits
Public
Copyright
Other

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