Circadian rhythmometry of mammalian radiosensitivityIn the case of human bone marrow, the largest number of mitoses is seen in the evening in diurnally active men, mitotic activity being at a minimum in the morning. The opposite pattern is observed for nocturnal animals such as rats and mice on a regimen of light during the daytime alternating with darkness during the night hours. The entirety of these rhythms plays an important role in the organism's responses to environmental stimuli, including its resistance to potentially harmful agents. Conditions under which circadian rhythms can be observed and validated by inferential statistical means are discussed while emphasizing how artifacts of the laboratory environment can be shown to obscure circadian periodic variations in radiosensitivity.
Document ID
19740060090
Acquisition Source
Legacy CDMS
Document Type
Other - Collected Works
Authors
Haus, E. (St. Paul-Ramsey Hospital and Medical Center St. Paul, Minn., United States)
Halberg, F. (Minnesota, University Minneapolis, Minn., United States)
Loken, M. K. (University of Minnesota Hospitals Minneapolis, Minn., United States)
Kim, Y. S. (Minnesota, University St. Paul, Minn., United States)