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The temporal organization of processes of cell reproduction and its connection with rhythms of radiosensitivity of the bodyRadiosensitivity of individual phases of the mitotic cycle was studied in synchronous cell cultures and in several biological objects. It was found that radiosensitivity changed essentially according to phases of the mitotic cycle, depending on the kind of cells, evaluation criteria and the radiation dosage. Tests on partially synchronized HeLa cell populations, according to the criterion of survival, showed them most sensitive during mitosis, as well as in later G sub 1- or early DNA-synthesizing stages. With radiation in doses of 300 rad, the proportion of surviving cells showed a sensitivity directly before DNA synthesis of approximately 4 times higher than the later S-phase and during the major portion of G sub 1- and G sub 2-periods. Sensitivity of cells in mitosis was approximately 3 times higher than in late G sub 1- and early S-phases.
Document ID
19750006349
Acquisition Source
Legacy CDMS
Document Type
Other
Authors
Druzhinin, Y. P.
(NASA Headquarters Washington, DC United States)
Romanov, Y. A.
(NASA Headquarters Washington, DC United States)
Vatsek, A.
(NASA Headquarters Washington, DC United States)
Date Acquired
August 8, 2013
Publication Date
January 1, 1974
Publication Information
Publication: The Function of the Body and Factors of Space Flight (NASA-TT-F-15971)
Subject Category
Aerospace Medicine
Accession Number
75N14421
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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