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The role of brain biogenic amines in the control of pituitary-adrenocortical activityIt was found that pretreatment of animals with desmethyl imipramine antagonized the reserpine-induced sedation without preventing the decline in brain amines or the hypersecretion of adrenocorticotropic hormone (ACTH). The antagonism of reserpine-induced ACTH hypersecretion by the monoamine oxidose (MAO) inhibitor pargyline (MO 911, N-methyl-N-benzyl-2-propynylamine) was studied. Evidence is presented that this antagonism is related to the level of brain biogenic amines maintained during the course of action of the drug. Pretreatment with MAO inhibitors does not affect the ACTH hypersecretion evoked by exposure to cold or chlorpromazine, lending further support to the hypothesis that reserpine-induced ACTH hypersecretion is related to brain amine changes.
Document ID
19750019663
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Authors
Maickel, R. P.
(Indiana Univ. Bloomington, IN, United States)
Date Acquired
August 8, 2013
Publication Date
June 1, 1975
Publication Information
Publication: NASA. Johnson Space Center Proc. of the 1973 JSC Endocrine Program Conf.
Subject Category
Aerospace Medicine
Accession Number
75N27735
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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