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Fine structural changes in the lateral vestibular nucleus of aging ratsThe fine structure of the lateral vestibular nucleus was investigated in Sprague-Dawley rats, that were sacrified at 4 weeks, 6-8 weeks, 6-8 months, and 18-20 months of age. In the neuronal perikaria, the following age-associated changes were seen with increasing frequency with advancing age: rodlike nuclear inclusions and nuclear membrane invaginations; cytoplasmic dense bodies with the characteristics of lipofuscin; and moderate disorganization of the granular endoplasmic reticulum. Dense bodies were also seen in glial cells. Rats 18 to 20 months old showed dendritic swellings, axonal degeneration, and an apparent increase in the number of axosomatic synaptic terminals containing flattened vesicles (presumed to be inhibitory in function).
Document ID
19750036970
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Johnson, J. E., Jr.
Miquel, J.
(NASA Ames Research Center Neurosciences Branch, Moffett Field, Calif., United States)
Date Acquired
August 8, 2013
Publication Date
January 1, 1974
Publication Information
Publication: Mechanisms of Ageing and Development
Volume: 3
Subject Category
Life Sciences (General)
Accession Number
75A21042
Funding Number(s)
CONTRACT_GRANT: NASA TASK 970-21-11-11
Distribution Limits
Public
Copyright
Other

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