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Effects of pharmacological agents on subcortical resistance shiftsMicroliter quantities of tetrodotoxin, tetraethylammonium chloride, and picrotoxin injected into the inferior colliculus and superior olive of unanesthetized cats differentially affect the amplitude and waveform of click-evoked potentials and evoked resistance shifts. Tetrodotoxin simultaneously reduces the negative phase of the evoked potential and eliminates the evoked resistance shift. Tetraethylammonium enhances the negative evoked potential component, presumably of postsynaptic origin, without significantly altering evoked resistance shift amplitude. Picrotoxin also enhances the negative evoked potential wave but increases evoked resistance shift amplitude. These findings implicate events associated with postsynaptic membrane depolarization in the production of the evoked resistance shift.
Document ID
19750063163
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Klivington, K. A.
(California, University La Jolla, Calif., United States)
Date Acquired
August 8, 2013
Publication Date
January 1, 1975
Publication Information
Publication: Experimental Neurology
Volume: 46
Subject Category
Life Sciences (General)
Accession Number
75A47235
Funding Number(s)
CONTRACT_GRANT: NGR-05-009-198
CONTRACT_GRANT: NIH-NS-10482-01
Distribution Limits
Public
Copyright
Other

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