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Increased rate of response of the pituitary-adrenal system in rats adapted to chronic stressThe response and adaptation of the pituitary-adrenal system to chronic stresses was investigated. These included individual caging, confinement, and exposure to cold for varying periods of time. Studies were carried out demonstrating that during the period of adaptation when plasma corticosterone concentrations returned toward their prestress level despite continued exposure to the stressor, the animals responded to additional stimuli of ether for 1 min, a saline injection, or release from confinement with a faster increase (within 2.5 min) in plasma corticosterone than controls (10 min). It is concluded that during adaptation to a chronic stress the pituitary-adrenal system is not inhibited by the circulating steroid level but is actually hypersensitive to additional stimuli.
Document ID
19760028172
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Sakellaris, P. C.
(NASA Ames Research Center Moffett Field, CA, United States)
Vernikos-Danellis, J.
(NASA Ames Research Center Biomedical Research Div., Moffett Field, Calif., United States)
Date Acquired
August 8, 2013
Publication Date
September 1, 1975
Publication Information
Publication: Endocrinology
Volume: 97
Subject Category
Life Sciences (General)
Accession Number
76A11138
Distribution Limits
Public
Copyright
Other

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