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Stress modification of the toxicity of antimotion sickness drugs and AspirinThe effect of environmental temperature on the toxicity of cyclizine, trimethobenzamide, and Aspirin were studied in mice. LD-50s were compared at 30 C, 22 C, and 15 C. At 30 C the toxicity of all three drugs increased, with that to Aspirin being affected most. Cooling decreased the toxicity of cyclizine and had no significant effect on that of trimethobenzamide or aspirin. These findings indicate that alterations in environmental temperature markedly affect drug toxicity. They emphasize that such alterations, and particularly increases in temperature, do not have to be particularly drastic, but that 'mild' variations in the environment are effective in altering an animal's sensitivity to a drug.
Document ID
19760029669
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Shields, D.
(NASA Ames Research Center Moffett Field, CA, United States)
Marra, C.
(NASA Ames Research Center Moffett Field, CA, United States)
Goodwin, A.
(NASA Ames Research Center Moffett Field, CA, United States)
Vernikos-Danellis, J.
(NASA Ames Research Center Biomedical Research Div., Moffett Field, Calif., United States)
Date Acquired
August 8, 2013
Publication Date
January 1, 1975
Publication Information
Publication: Pharmacology
Volume: 13
Subject Category
Life Sciences (General)
Accession Number
76A12635
Distribution Limits
Public
Copyright
Other

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