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Renal effects of continuous negative pressure breathingContinuous negative pressure breathing (CNPB) was utilized to simulate the thoracic vascular distension of zero G in 11 anesthetized rats. The animals underwent renal clearance and micropuncture renal nephron studies before, during, and after CNPB. Four rats were pretreated with a high salt diet and I-M desoxycorticosterone (DOCA) in excess. None of these rats diuresed with CNPB. In contrast, five of the seven remaining rats increased the fraction of the filtered sodium excreted and their urinary flow rate. Potassium excretion increased. End proximal tubular fluid specimen's TF/P inulin ratios were unchanged. Whole kidney and single nephron glomerular filtration rates fell 10%. CNPB, a mechanism for atrial distension, appears to cause in the rat a decrease in distal tubular sodium and water reabsorption. Exogenous mineral-corticoid prevents the diuresis, saluresis, and kaluresis. The adequacy of other nonatrial volume control mechanisms in regulating renal salt and water conservation in opposition to the studied atrial-renal (Henry-Gauer) reflex of thoracic vascular distension is confirmed.
Document ID
19760030615
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Kinney, M. J.
(U.S. Public Health Service Hospital Staten Island, N.Y., United States)
Date Acquired
August 8, 2013
Publication Date
November 1, 1975
Subject Category
Aerospace Medicine
Accession Number
76A13581
Funding Number(s)
CONTRACT_GRANT: NASA ORDER T-2950-A
PROJECT: PHS PROJECT SI-75-32-73
Distribution Limits
Public
Copyright
Other

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