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Role of arterial baroreceptors in mediating cardiovascular response to exerciseExperiments were conducted to define the role of the major arterial baroreceptors during moderately severe exercise by comparing the responses of untethered conscious dogs instrumented for the measurement of aortic pressure and cardiac output with those of dogs with total arterial baroreceptor denervation. The reflex heart rate responses to intravenous bolus doses of methoxamine were also examined in intact animals, both at rest and during exercise. Methoxamine is found to cause striking bradycardia at rest, but little bradycardia during exercise. Experimental findings suggest that the arterial baroreceptor reflex is normally inhibited during severe exercise and therefore plays little role in modulating the cardiovascular response to exercise.
Document ID
19760038088
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Mcritchie, R. J.
(Childrens Hospital Medical Center Boston, MA, United States)
Vatner, S. F.
(Childrens Hospital Medical Center Boston, MA, United States)
Patrick, T. A.
(Childrens Hospital Medical Center Boston, MA, United States)
Braunwald, E.
(Harvard University, Cambridge; Peter Bent Brigham Hospital; Children's Hospital Medical Center Boston; New England Regional Primate Research Center, Southborough, Mass., United States)
Boettcher, D.
(Childrens Hospital Medical Center Boston, MA, United States)
Heyndrickx, G. R.
(Childrens Hospital Medical Center Boston, MA, United States)
Date Acquired
August 8, 2013
Publication Date
January 1, 1976
Publication Information
Publication: American Journal of Physiology
Volume: 230
Subject Category
Life Sciences (General)
Accession Number
76A21054
Funding Number(s)
CONTRACT_GRANT: PHS-HL-10436-09
CONTRACT_GRANT: PHS-HL-17549
CONTRACT_GRANT: PHS-HL-15416
Distribution Limits
Public
Copyright
Other

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