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Cerebellar pressor response in the dogA fastigial pressor response has been elicited in the anesthetized mongrel dog. Stimulation within the rostral portions of this nucleus results in mean arterial pressure rises up to 150 mmHg above control. A proportional tachycardia is simultaneously evoked which may rapidly attain heart rates of 190 beats/min above control levels. Peak tachycardias immediately subside and often the heart rate declines below control values during stimulation while arterial pressure remains elevated. When either the carotid sinuses were isolated by ligation or a bilateral vagotomy was performed, the fastigial tachycardia was sustained. The response could still be attained when submaximal doses of alpha-chloralose anesthesia or high levels of barbiturates (30-40 mg/kg) were given. Both portions of the response result from widespread sympathetic activation; however, buffering of the response through the baroreceptor reflexes is only demonstrated in the cardiac segment of the response.
Document ID
19770028248
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Dormer, K. J.
(Texas Univ. Galveston, TX, United States)
Stone, H. L.
(Texas, University Galveston, Tex., United States)
Date Acquired
August 8, 2013
Publication Date
October 1, 1976
Publication Information
Publication: Journal of Applied Physiology
Volume: 41
Subject Category
Life Sciences (General)
Accession Number
77A11100
Funding Number(s)
CONTRACT_GRANT: NGR-44-088-002
CONTRACT_GRANT: NIH-HL-05145
Distribution Limits
Public
Copyright
Other

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