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Reduction in plasma vasopressin levels of dehydrated rats following acute stressResults are presented for an investigation directed to substantiate and extend preliminary findings of stress-induced reduction in plasma arginine vasopressin (pAVP). Since normally hydrated rats have very low levels of pAVP, it is difficult to measure reliably any decrease in pAVP that may result from stress. To overcome this problem, the pAVP levels of the tested rats were raised by dehydration prior to application of stress. A radioimmunoassay for pAVP is described and used to determine the levels of vasopressin in the plasma of nondehydrated and dehydrated rats after exposure to ether or acceleration stress. Plasma pAVP is also determined in rats following nicotine administration. It is shown that exposure of nondehydrated rats to ether or acceleration stress does not elicit any significant alterations in circulating pAVP levels while nicotine injections stimulate a marked increase. In particular, ether and acceleration stress produce a rapid reduction in the pAVP level of dehydrated rats, the decrease being observed in both large and small animals. The mechanism for this reduction in pAVP level following stress is yet unknown.
Document ID
19770042295
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Keil, L. C.
(NASA Ames Research Center Moffett Field, Calif., United States)
Severs, W. B.
(M. S. Hershey Medical Center Hershey, Pa., United States)
Date Acquired
August 8, 2013
Publication Date
January 1, 1977
Publication Information
Publication: Endocrinology
Volume: 100
Subject Category
Life Sciences (General)
Accession Number
77A25147
Distribution Limits
Public
Copyright
Other

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