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The use of a behavioral response system in the USF/NASA toxicity screening test methodRelative toxicity data on the pyrolysis effluents from bisphenol A polycarbonate and wool fabric were obtained, based on visual observations of the behavior of free-moving mice and on an avoidance response behavioral paradigm of restrained rats monitored by an instrumented behavioral system. The initial experiments show an essentially 1:1 correlation between the two systems with regard to first signs of incapacitation, collapse, and death from pyrolysis effluents from polycarbonate. It is hypothesized that similarly good correlations between these two systems might exist for other materials exhibiting predominantly carbon monoxide mechanisms of intoxication. This hypothesis needs to be confirmed, however, by additional experiments. Data with wool fabric exhibited greater variability with both procedures, indicating possibly different mechanisms of intoxication for wool as compared with bisphenol A polycarbonate.
Document ID
19770067775
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Hilado, C. J.
(San Francisco Univ. CA, United States)
Cumming, H. J.
(San Francisco, University San Francisco, Calif., United States)
Packham, S. C.
(Physio-Behavioral Consultants Salt Lake City, Utah, United States)
Date Acquired
August 9, 2013
Publication Date
August 1, 1977
Publication Information
Publication: Journal of Combustion Toxicology
Volume: 4
Subject Category
Life Sciences (General)
Accession Number
77A50627
Funding Number(s)
CONTRACT_GRANT: NSG-2039
Distribution Limits
Public
Copyright
Other

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