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A review of available LC/50/ dataSeveral gaseous products of pyrolysis and combustion have been evaluated for LC/50/, defined as the concentration of toxic gas in the atmosphere being inhaled by test animals that will produce death in 50% of the animals within a given time period. The products tested included CO, HCl, HF, HCN, NO2, and SO2. It was found that HCN and NO2 were consistently the most toxic of the gases reviewed, and that mice were more susceptible than rats to HCl and HF, although less susceptible than rats to NO2. Extrapolation of LC/50/ data to humans indicates that metabolic rate may be a valid basis for extrapolation when the toxicity mechanism is interference with oxygen transport and utilization, or pulmonary edema, but not when it is irritation and damage to the upper respiratory tract.
Document ID
19770067786
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Hilado, C. J.
(San Francisco Univ. CA, United States)
Cumming, H. J.
(San Francisco, University San Francisco, Calif., United States)
Date Acquired
August 9, 2013
Publication Date
August 1, 1977
Publication Information
Publication: Journal of Combustion Toxicology
Volume: 4
Subject Category
Life Sciences (General)
Accession Number
77A50638
Funding Number(s)
CONTRACT_GRANT: NSG-2039
Distribution Limits
Public
Copyright
Other

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