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Spatial distribution of pulmonary blood flow in dogs in increased force environmentsSpatial distribution of pulmonary blood flow during 2- to 3-min exposures to 6-8 Gy acceleration was studied, using radioactive microspheres in dogs, and compared to previously reported 1 Gy control distributions. Isotope distributions were measured by scintiscanning individual 1-cm-thick cross sections of excised, fixed lungs. Results indicate: (1) the fraction of cardiac output traversing left and right lungs did not change systematically with the duration and magnitude of acceleration; but (2) the fraction is strongly affected by the occurrence or absence of fast deep breaths, which cause an increase or decrease, respectively, in blood flow through the dependent lung; and (3) Gy acceleration caused a significant increase in relative pulmonary vascular resistance (PVR) in nondependent and dependent regions of the lung concurrent with a decrease in PVR in the midsagittal region of the thorax.
Document ID
19780045123
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Greenleaf, J. F.
(Mayo Clinic Rochester, MN, United States)
Ritman, E. L.
(Mayo Clinic Rochester, MN, United States)
Chevalier, P. A.
(Mayo Clinic Rochester, MN, United States)
Sass, D. J.
(Mayo Clinic Rochester, MN, United States)
Wood, E. H.
(Mayo Clinic; Mayo Foundation Rochester, Minn., United States)
Date Acquired
August 9, 2013
Publication Date
March 1, 1978
Publication Information
Publication: Journal of Applied Physiology: Respiratory
Subject Category
Life Sciences (General)
Accession Number
78A29032
Funding Number(s)
CONTRACT_GRANT: NIH-CI-10
CONTRACT_GRANT: NIH-RR-7
CONTRACT_GRANT: NIH-HL-04664
CONTRACT_GRANT: NGR-24-003-001
CONTRACT_GRANT: F49620-76-C-0001
Distribution Limits
Public
Copyright
Other

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