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Formation of the imidazolides of dinucleotides under potentially prebiotic conditionsImidazolides of dinucleotides such as ImpApA can be formed from the corresponding dinucleotides in a two-stage process, which gives up to 15% yields under potentially prebiotic conditions. First a solution of the dinucleotide and sodium trimetaphosphate is dried out at constant temperature and humidity. This produces polyphosphates such as p(n)ApA in excellent yield (greater than or equal to 80%). The products are dissolved in water, imidazole is added, and the solution is dried out again. This yields the 5'-phosphorimidazolides.
Document ID
19780058933
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Sleeper, H. L.
(Salk Inst. for Biological Studies San Diego, CA, United States)
Lohrmann, R.
(Salk Inst. for Biological Studies San Diego, CA, United States)
Orgel, L. E.
(Salk Institute for Biological Studies San Diego, Calif., United States)
Date Acquired
August 9, 2013
Publication Date
June 20, 1978
Publication Information
Publication: Journal of Molecular Evolution
Volume: 11
Subject Category
Chemistry And Materials (General)
Accession Number
78A42842
Funding Number(s)
CONTRACT_GRANT: NGR-05-067-001
Distribution Limits
Public
Copyright
Other

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