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Neutral changes during divergent evolution of hemoglobinsA comparison of the mRNAs for rabbit and human beta-hemoglobins shows that synonymous changes in codons have accumulated three times as rapidly as nucleotide replacements that produced changes in amino acids. This agrees with predictions based on the so-called neutral theory. In addition, seven codon changes that appear to be single-base changes (according to maximum parsimony) are actually two-base changes. This indicates that the construction of primordial sequences is of limited significance when based on inferences that assume minimum base changes for amino acid replacements.
Document ID
19780063984
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Jukes, T. H.
(California, University Berkeley, Calif., United States)
Date Acquired
August 9, 2013
Publication Date
August 2, 1978
Publication Information
Publication: Journal of Molecular Evolution
Volume: 11
Subject Category
Life Sciences (General)
Accession Number
78A47893
Funding Number(s)
CONTRACT_GRANT: NGR-05-003-460
Distribution Limits
Public
Copyright
Other

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