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Studies on the erythron and the ferrokinetic responses in beagles adapted to hypergravityRed cell survival, ferrokinetics, and hematologic parameters were investigated in beagle dogs exposed to chronic hypergravity (2.6 Gx). Ineffective erythropoiesis, red cell mass, plasma volume, and Cr-51-elution were significantly increased; maximum Fe-59 incorporation was decreased; and there was no change in the mean erythrocyte life span following autologous injection of Cr-51-labeled red cells and Fe-59-labeled transferrin. Red cell count, F(cells), total body hemoglobin (Hb), susceptability to osmotic lysis, and differential reticulocyte count were increased. White blood cell count, venous blood %Hb, mean cell volume, mean cell Hb, mean cell Hb concentration, and serum iron were decreased. No changes were observed for body mass, mg Fe per g Hb, iron binding capacity, percent saturation of iron carrying capacity, or the electrophoretic mobility of purified Hb. This study indicated that chronic exposure to hypergravity induced changes in red cell size, volume, total mass, and membrane permeability.
Document ID
19790028856
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Beckman, D. A.
(California Univ. Davis, CA, United States)
Evans, J. W.
(California, University Davis, Calif., United States)
Oyama, J.
(NASA Ames Research Center Biomedical Research Div., Moffett Field; California, University, Davis, Calif., United States)
Date Acquired
August 9, 2013
Publication Date
November 1, 1978
Subject Category
Life Sciences (General)
Accession Number
79A12869
Funding Number(s)
CONTRACT_GRANT: NCA2-OR180-505
Distribution Limits
Public
Copyright
Other

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