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Response of the rat erythrocyte to ozone exposureSprague-Dawley rats were exposed to high (6-8 ppm) and moderate (1.5 ppm) amounts of ozone (O3) for various time periods. Response of the rat erythrocyte to ozone was monitored with red blood cell potassium (rubidium) influx studies, with storage stress combined with ultrastructural studies and with levels of erythrocyte glutathione peroxidase and superoxide dismutase. Erythrocytes of rats exposed to O3 showed no significant changes either in their potassium influx or in their glutathione peroxidase and superoxide dismutase activities compared to controls. Erythrocyte differential counts on O3-exposed animals showed significant changes initially as well as following storage stress compared to controls. Rats exposed to 8 ppm O3 for 4 h showed a marked increase in echinocytes. These consistent transformations from discocytes to echinocytes following O3 exposure suggest latent erythrocyte damage has occurred.
Document ID
19790034950
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Larkin, E. C.
(California, University Davis, Calif., United States)
Kimzey, S. L.
(U.S. Veterans Administration Hospital Martinez, Calif., United States)
Siler, K.
(NASA Johnson Space Center Houston, Tex., United States)
Date Acquired
August 9, 2013
Publication Date
December 1, 1978
Publication Information
Publication: Journal of Applied Physiology: Respiratory
Subject Category
Life Sciences (General)
Accession Number
79A18963
Funding Number(s)
CONTRACT_GRANT: PHS-RR-00169
CONTRACT_GRANT: NASA ORDER T-52981-D
CONTRACT_GRANT: PHS-ESHL-00628-06
CONTRACT_GRANT: PHS-HL-17957-03
Distribution Limits
Public
Copyright
Other

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