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Beta-galactosidase and selective neutralityThree hypotheses to explain the amino acid composition of proteins are inconsistent (about 10 to the minus 9th) with the experimental data for beta-galactosidase from Escherichia coli. The exceptional length of this protein, 1021 residues, permits rigorous tests of these hypotheses without complication from statistical artifacts. Either this protein is not at compositional equilibrium, which is unlikely from knowledge about other proteins, or the evolution of this protein and its coding gene have not been selectively neutral. However, the composition of approximately 60% of the molecule is consistent with either a selectively neutral or nonneutral evolutionary process.
Document ID
19790042156
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Holmquist, R.
(California, University Berkeley, Calif., United States)
Date Acquired
August 9, 2013
Publication Date
March 9, 1979
Publication Information
Publication: Science
Volume: 203
Subject Category
Life Sciences (General)
Accession Number
79A26169
Funding Number(s)
CONTRACT_GRANT: NSF PCM-76-18627
CONTRACT_GRANT: NGR-05-003-460
Distribution Limits
Public
Copyright
Other

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