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Weight control and restraint of laboratory ratsThe use of restrained and confined rats in some procedures used in combustion toxicology introduces the problems of obtaining rats of the appropriate size for the apparatus, and of identifying any artifacts resulting from the use of restraint alone. Feeding studies indicate that controlled feeding of fast-growing strains such as the Sprague-Dawley can hold rat size essentially constant for significant periods of time. The undesirable aspects are the need to cage the animals individually, with resultant psychological as well as metabolic effects. Restraint studies of slow-growing strains such as the Fischer 344 indicate that denying access to food and water for periods of several hours at a time interrupts normal gain only temporarily.
Document ID
19790042571
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Hilado, C. J.
(San Francisco Univ. CA, United States)
Van Breda Kolff, K.
(San Francisco, University San Francisco, Calif., United States)
Date Acquired
August 9, 2013
Publication Date
February 1, 1979
Publication Information
Publication: Journal of Combustion Toxicology
Volume: 6
Subject Category
Life Sciences (General)
Accession Number
79A26584
Funding Number(s)
CONTRACT_GRANT: NSG-2039
Distribution Limits
Public
Copyright
Other

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