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The catalysis of nucleotide polymerization by compounds of divalent leadThe nonenzymatic, nontemplate catalysis of nucleotide polymerization by Pb(2+) ions, a possible prebiotic catalyst, is reported. Adenosine and uridine phosphoimidazoles were reacted in buffered solutions of lead salts and products were analyzed by means of paper chromatography and electrophoresis. In the presence of Pb(2+) ion at pH 8.0 and 7.0 the reaction is found to progress rapidly with excellent yields of oligomers, with optimal yields observed at pH 8.0. Little temperature dependence in the range 0 to 30 C is observed, however hydrolysis of the reaction products is minimal when the reaction is carried out at 0 C. Results show that the yield of oligomers is insensitive to mixing or the source of lead ions, indicating that naturally occurring minerals or precipitates could be a source of Pb(2+) ions under prebiotic conditions.
Document ID
19790048911
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Sleeper, H. L.
(Salk Inst. for Biological Studies San Diego, CA, United States)
Orgel, L. E.
(Salk Institute for Biological Studies San Diego, Calif., United States)
Date Acquired
August 9, 2013
Publication Date
April 12, 1979
Publication Information
Publication: Journal of Molecular Evolution
Volume: 12
Subject Category
Chemistry And Materials (General)
Accession Number
79A32924
Funding Number(s)
CONTRACT_GRANT: NGR-05-067-001
Distribution Limits
Public
Copyright
Other

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