Prebiotic condensation reactions using cyanamideCondensation reactions in cyanamide, 4-amino-5-imidazole-carboxamide and cyanamide, imidazole systems under dehydrating conditions at moderate temperatures (60 to 100 deg C) were investigated. The cyanamide, imidazole system was used for synthesis of palmitoylglycerols from ammonium palmitate and glycerol. With the addition of deoxythymidine to the former system, P1, P2-dideoxythymidine 5 prime-phosphate was obtained; the same cyanamide, 4-amino-5-imidazole-carboxamide system was used to synthesize deoxythymidine oligonucleotides using deoxythymidine 5 prime-phosphate and deoxythymidine 5 prime-triphosphate, and peptides using glycine, phenylalanine or isoleucine with adenosine 5 prime-triphosphate. The pH requirements for these reactions make their prebiotic significance questionable; however, it is conceivable that they could occur in stable pockets of low interlayer acidity in a clay such as montmorillonite.
Document ID
19790053919
Acquisition Source
Legacy CDMS
Document Type
Conference Proceedings
Authors
Sherwood, E. (Houston Univ. TX, United States)
Nooner, D. W. (Houston Univ. TX, United States)
Eichberg, J. (Houston Univ. TX, United States)
Epps, D. E. (Houston Univ. TX, United States)
Oro, J. (Houston, University Houston, Tex., United States)
Date Acquired
August 9, 2013
Publication Date
January 1, 1978
Subject Category
Space Biology
Meeting Information
Meeting: Origin of life; Second ISSOL Meeting and Fifth ICOL Meeting