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Nucleoside phosphorylation in amide solutionsThe paper deals with phosphorylation in possible prebiotic nonaqueous solvents. To this end, phosphorylation of nucleosides using inorganic phosphates in amide solutions is studied at room and elevated temperatures. Reaction proceeds most readily in formamide and N-methylformamide. Products obtained at elevated temperature are nucleotides, nucleoside 2',3'-cyclic phosphates, and when the phosphate concentration is high, nucleoside diphosphates. At room temperature, adenosine afforded a mixture of nucleotides, but none of the cyclic nucleotide. Conditions leading to the highest relative percentage of cyclic nucleotide involve the use of low concentrations of phosphate and an excess of nucleoside.
Document ID
19790053927
Acquisition Source
Legacy CDMS
Document Type
Conference Proceedings
Authors
Schoffstall, A. M.
(Colorado, University Colorado Springs, Colo.; Maryland, University, College Park, Md., United States)
Kokko, B.
(Colorado, University Colorado Springs, Colo., United States)
Date Acquired
August 9, 2013
Publication Date
January 1, 1978
Subject Category
Chemistry And Materials (General)
Meeting Information
Meeting: Origin of life; Second ISSOL Meeting and Fifth ICOL Meeting
Location: Kyoto
Country: Japan
Start Date: April 5, 1977
End Date: April 10, 1977
Accession Number
79A37940
Funding Number(s)
CONTRACT_GRANT: NGR-21-002-317
Distribution Limits
Public
Copyright
Other

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