NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Low tryptophan diet decreases brain serotonin and alters response to apomorphineThe role of the serotoninergic system in the regulation of apomorphine-induced behavior, a behavior primarily controlled by dopaminergic neurotransmission, was investigated in rats fed on a low tryptophan diet since weaning. It was found that reductions in brain seritonin (5-HT) produced by diet result in decreased stereotypy after apomorphine administration. This indicates that although stereotyped behavior is primarily mediated by dopaminergic mechanisms, it can also be modulated by other neurotransmitter including 5-HT. It was also shown that changes in brain seritonin levels can affect psychomotor stimulant-induced hypothermia.
Document ID
19790056659
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Sahakian, B. J.
(MIT, Cambridge; Massachusetts, University Worcester, Mass., United States)
Wurtman, R. J.
(Massachusetts Inst. of Tech. Cambridge, MA, United States)
Barr, J. K.
(Massachusetts Inst. of Tech. Cambridge, MA, United States)
Millington, W. R.
(Massachusetts Inst. of Tech. Cambridge, MA, United States)
Chiel, H. J.
(MIT Cambridge, Mass., United States)
Date Acquired
August 9, 2013
Publication Date
June 21, 1979
Publication Information
Publication: Nature
Volume: 279
Subject Category
Life Sciences (General)
Accession Number
79A40672
Funding Number(s)
CONTRACT_GRANT: NGR-22-009-627
CONTRACT_GRANT: NIH-AM-14228
Distribution Limits
Public
Copyright
Other

Available Downloads

There are no available downloads for this record.
No Preview Available