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Studies on the bioassayable growth hormone-like activity of plasmaEvidence supporting the existence of bioassayable growth hormone-like activity in blood plasma distinct from the growth hormone measurable by radioimmunoassay and from somatomedin is presented. Tibial assays of the growth-hormone-like activity of injected, concentrated normal human and rat plasma in hypophysectomized rats reveal 200- and 50-fold activity excesses, respectively, with respect to the amount of growth hormone detected by radioimmunoassay. The origin of this bioassayable plasma hormone has been localized to the region of the pituitary, the origin of growth hormone, a distribution not followed by somatomedin C. Purification of the bioassayable agent indicates that is has a molecular weight of between 60,000 and 80,000, in contrast to that of growth hormone (20,000), and that the bioassayable activity is distinct from that of somatomedin C. Growth hormone-like activity detected in Cohn fraction IV as well as plasma activity, are found to be collectable on Dowex 50 resin, in contrast to somatomedin C and nonsuppressible insulin-like activity. The formation of bioassayable growth hormone-activity agents from radioimmunoassayable growth hormone and directly in the pituitary is suggested.
Document ID
19790063835
Acquisition Source
Legacy CDMS
Document Type
Other - Collected Works
Authors
Ellis, S.
(NASA Ames Research Center Moffett Field, CA, United States)
Vodian, M. A.
(NASA Ames Research Center Moffett Field, CA, United States)
Grindeland, R. E.
(NASA Ames Research Center Biomedical Research Div., Moffett Field, Calif., United States)
Date Acquired
August 9, 2013
Publication Date
January 1, 1978
Subject Category
Life Sciences (General)
Accession Number
79A47848
Distribution Limits
Public
Copyright
Other

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