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Template-directed synthesis of oligoadenylates catalyzed by Pb/2+/ ionsThe Pb(2+) ion is an effective catalyst for the template-directed condensation of ImpA on poly(U). This reaction generates up to 35% of oligomers 5 or more units long. Furthermore, the product is predominantly 3'-5'-linked (75%) unlike that from the uncatalyzed reaction which is more than 90% 2'-5'-linked. The significance of metal-ion catalysis for prebiotic polynucleotide formation is discussed.
Document ID
19800027301
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Sleeper, H. L.
(Salk Inst. for Biological Studies San Diego, CA, United States)
Lohrmann, R.
(Salk Inst. for Biological Studies San Diego, CA, United States)
Orgel, L. E.
(Salk Institute for Biological Studies San Diego, Calif., United States)
Date Acquired
August 10, 2013
Publication Date
January 1, 1979
Publication Information
Publication: Journal of Molecular Evolution
Volume: 13
Issue: 3, 19
Subject Category
Chemistry And Materials (General)
Accession Number
80A11471
Funding Number(s)
CONTRACT_GRANT: NGR-05-067-001
Distribution Limits
Public
Copyright
Other

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