NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Self-condensation of activated dinucleotides on polynucleotide templates with alternating sequencesSubstantial quantities of the alternating polymers poly(U-G) and poly(C-A) have been prepared and used as templates for the self-condensation of ImpApC, ImpCpA, ImpGpU and ImpUpG. It is found that the condensation of ImpGpu and ImpUpG on poly(C-A) is efficient, the condensation of ImpCpA on poly(U-G) is moderately efficient, while the condensation of ImpApC on poly(U-C) proceeds poorly. In many cases, the product is predominantly 3'-5'-linked. These reactions demonstrate unequivocally, for the first time, that template-directed reactions occur in double-helical structures. Furthermore, they describe for the first time a pair of reactions in which each of two complementary polymers facilitates the synthesis of the other. The prebiotic significance of these findings is discussed.
Document ID
19800041032
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Lohrmann, R.
(Salk Inst. for Biological Studies San Diego, CA, United States)
Orgel, L. E.
(Salk Institute for Biological Studies San Diego, Calif., United States)
Date Acquired
August 10, 2013
Publication Date
December 1, 1979
Publication Information
Publication: Journal of Molecular Evolution
Volume: 14
Subject Category
Life Sciences (General)
Accession Number
80A25202
Funding Number(s)
CONTRACT_GRANT: NGR-05-067-001
CONTRACT_GRANT: NIH-GM-13435
Distribution Limits
Public
Copyright
Other

Available Downloads

There are no available downloads for this record.
No Preview Available