Thermal copoly/amino acids/ as inhibitors of glyoxalase IA number of copoly(alpha-amino acids) have been prepared thermally; some have been found to function as inhibitors of glyoxalase I, an enzyme which occupies a central position in Szent-Gyorgyi's theory of tumour genesis. These polymers are also of interest in the search for synthetic peptides having carcinostatic activity, since many natural peptides are active. The way in which the inhibitory activity varies with composition of the synthetic polymers has been investigated. Various properties (hydrophobicity, molecular weight, UV absorption, kinetic type) have been examined in a search for correlates of inhibitory activity.
Document ID
19800048661
Acquisition Source
Legacy CDMS
Document Type
Other - Collected Works
Authors
Fox, S. W. (Miami Univ. Coral Gables, FL, United States)
Syren, R. M. (Miami Univ. Coral Gables, FL, United States)
Windsor, C. R. (Miami, University Coral Gables, Fla., United States)