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Experiment K304: Studies of specific hepatic enzymes and liver constituents involved in the conversion of carbohydrates to lipids in rats exposed to prolonged space flightThe effects of space flight on the activities of 26 enzymes concerned with carbohydrate and lipid metabolism in hepatic tissue taken from male Wistar rats are investigated. These activities were measured in the various hepatic cell compartments, i.e., cytosol, mitochondria and microsomes. In addition, the levels of glycogen, total lipids, phospholipids, triglycerides, cholesterol, cholesterol esters, and the fatty acid composition of the rat livers were also examined and quantified. A similar group of ground-based rats treated in an identical manner served as controls. Both flight and synchronous control rats were sacrificed at three time intervals: R+0, 7-11 hours after recovery; R+6, after 6 days; R+6(S), after 6 days (having undergone 2-5 hour periods of fixed stress in a "backupward" position on days 0, 3, 4, 5 and 6) and R+29, after 29 days post-flight. Although most of the enzyme activities and the amounts of liver constituents studied were unaffected by the period of weightlessness, some significant differences were observed.
Document ID
19810024288
Acquisition Source
Legacy CDMS
Document Type
Other
Authors
Abraham, S.
(Children's Hospital Medical Center Oakland, Calif., United States)
Klein, H. P.
(NASA Ames Research Center Moffett Field, CA, United States)
Lin, C. Y.
(Children's Hospital Medical Center Oakland, Calif., United States)
Volkmann, C.
(NASA Ames Research Center Moffett Field, CA, United States)
Tigranyan, R. A.
(Inst. of Medical and Biological Problems Moscow, United States)
Vetrova, E. G.
(Inst. of Medical and Biological Problems Moscow, United States)
Date Acquired
August 11, 2013
Publication Date
August 1, 1981
Publication Information
Publication: US Rat Expts. Flown on the Soviet Satellite Cosmos 1129
Subject Category
Life Sciences (General)
Accession Number
81N32831
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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