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Antihistamine effect on synaptosomal uptake of serotonin, norepinephrine and dopamineA study on the effects of five H1 and H2 antihistamines on the synaptosomal uptake of serotonin (5HT), norepinephrine (NE), and dopamine (DA) is presented. Brain homogenates from female rats were incubated in Krebs-Ringer phosphate buffer solution in the presence of one of three radioactive neurotransmitters, and one of the five antihistamines. Low concentrations of pyrilamine competitively inhibited 5HT uptake, had little effect on NE uptake, and no effect on DA uptake. Promethazine, diphenhydramine, metiamide, and cimetidine had no effect on 5HT or DA uptake at the same concentration. Diphenhydramine had a small inhibitory effect on NE uptake. It is concluded that pyrilamine is a selective and potent competitive inhibitor of 5HT uptake at concentrations between .05 and .5 micromolars.
Document ID
19810040559
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Brown, P. A.
(NASA Ames Research Center Moffett Field, CA, United States)
Vernikos, J.
(NASA Ames Research Center Biomedical Research Div., Moffett Field, Calif., United States)
Date Acquired
August 11, 2013
Publication Date
January 1, 1980
Publication Information
Publication: European Journal of Pharmacology
Volume: 65
Subject Category
Aerospace Medicine
Accession Number
81A24963
Funding Number(s)
CONTRACT_GRANT: NCA2-OR-675-710
Distribution Limits
Public
Copyright
Other

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