Modelling of DNA-protein recognitionComputer model-building procedures using stereochemical principles together with theoretical energy calculations appear to be, at this stage, the most promising route toward the elucidation of DNA-protein binding schemes and recognition principles. A review of models and bonding principles is conducted and approaches to modeling are considered, taking into account possible di-hydrogen-bonding schemes between a peptide and a base (or a base pair) of a double-stranded nucleic acid in the major groove, aspects of computer graphic modeling, and a search for isogeometric helices. The energetics of recognition complexes is discussed and several models for peptide DNA recognition are presented.
Document ID
19810057823
Acquisition Source
Legacy CDMS
Document Type
Other - Collected Works
Authors
Rein, R. (Roswell Park Memorial Inst. Buffalo, NY, United States)
Garduno, R. (Roswell Park Memorial Inst. Buffalo, NY, United States)
Colombano, S. (Roswell Park Memorial Inst. Buffalo, NY, United States)
Nir, S. (Roswell Park Memorial Inst. Buffalo, NY, United States)
Haydock, K. (Roswell Park Memorial Institute, Buffalo; New York State University Amherst, NY, United States)
Macelroy, R. D. (NASA Ames Research Center Moffett Field, CA; Roswell Park Memorial Institute, Buffalo; New York State University, Amherst, NY, United States)