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Suppression of osteoblast differentiation during weightlessnessIt is pointed out that associated with weightlessness is a marked depression or arrest of bone formation. Although the mechanism of this effect is unknown, it probably involves a failure of osteogenic induction. The present study's objective is to determine if weightlessness alters osteoblast differentiation, as evidenced by a change in relative distribution of large to small nuclei in rat moral periodontal ligament of the maxilla. In conjunction with the U.S./USSR Biological Satellite Program, male Wistar rats were flown aboard a modified Soviet Vostok spacecraft (Cosmos 1129). The results of the study are discussed. Morphometric investigations suggest that depleted numbers of preosteoblasts may be an important factor in the inhibition of bone formation during weightlessness.
Document ID
19820057221
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Roberts, W. E.
(NASA Ames Research Center Moffett Field, CA, United States)
Mozsary, P. G.
(University of the Pacific San Francisco, CA, United States)
Morey, E. R.
(NASA Ames Research Center Moffett Field, CA, United States)
Date Acquired
August 10, 2013
Publication Date
January 1, 1982
Subject Category
Life Sciences (General)
Accession Number
82A40756
Funding Number(s)
CONTRACT_GRANT: NIH-2-S07-RR-05301
CONTRACT_GRANT: NIH-DE-05136
CONTRACT_GRANT: NCA2-OR-588-002
Distribution Limits
Public
Copyright
Other

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