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The chemical structure of DNA sequence signals for RNA transcriptionThe proposed recognition sites for RNA transcription for E. coli NRA polymerase, bacteriophage T7 RNA polymerase, and eukaryotic RNA polymerase Pol II are evaluated in the light of the requirements for efficient recognition. It is shown that although there is good experimental evidence that specific nucleic acid sequence patterns are involved in transcriptional regulation in bacteria and bacterial viruses, among the sequences now available, only in the case of the promoters recognized by bacteriophage T7 polymerase does it seem likely that the pattern is sufficient. It is concluded that the eukaryotic pattern that is investigated is not restrictive enough to serve as a recognition site.
Document ID
19830038190
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
George, D. G.
(National Biomedical Research Foundation Washington, DC, United States)
Dayhoff, M. O.
(National Biomedical Research Foundation Washington, DC, United States)
Date Acquired
August 11, 2013
Publication Date
September 1, 1982
Subject Category
Life Sciences (General)
Accession Number
83A19408
Funding Number(s)
CONTRACT_GRANT: NASW-3317
Distribution Limits
Public
Copyright
Other

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