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Computer simulation analysis of the behavior of renal-regulating hormones during hypogravic stressA computer simulation of a mathematical circulation model is used to study the alterations of body fluids and their electrolyte composition that occur in weightlessness. The behavior of the renal-regulating hormones which control these alterations is compared in simulations of several one-g analogs of weightlessness and space flight. It is shown that the renal-regulating hormones represent a tightly coupled system that responds acutely to volume disturbances and chronically to electrolyte disturbances. During hypogravic conditions these responses lead to an initial suppression of hormone levels and a long-term effect which varies depending on metabolic factors that can alter the plasma electrolytes. In addition, it is found that if pressure effects normalize rapidly, a transition phase may exist which leads to a dynamic multiphasic endocrine response.
Document ID
19830046576
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Leonard, J. I.
(GE Management and Technical Services Co. Houston, TX, United States)
Date Acquired
August 11, 2013
Publication Date
December 1, 1982
Subject Category
Aerospace Medicine
Accession Number
83A27794
Funding Number(s)
CONTRACT_GRANT: NAS9-16328
Distribution Limits
Public
Copyright
Other

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