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Hormonal changes in antiorthostatic ratsHypokinesia, especially hypokinesia with negative tilt ('antiorthostatic hypokinesia'), mimics some of the effects of weightlessness. It is shown that cardiac output is increased during early exposure of rats to antiorthostatic hypokinesia. The increase of the stroke volume and of the cardiac output observed in the antiorthostatic hypokinetic rats is probably the consequence of a blood volume shift toward the chest brought forth by head-down positioning of the animals. It is also possible that struggling of the animals to escape from the harness and an increased metabolism contribute to the elevation of cardiac output. In order to study this hypothesis 'stress hormones' were measured in the antiorthostatic rats. Plasma levels of ACTH, corticosterone and prolactin were measured in the arterial blood (0.3 ml) sampled before, during and after hypokinesia from chronic aortic cannulas of the rats.
Document ID
19830046582
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Popovic, V.
(Emory Univ. Atlanta, GA, United States)
Popovic, P.
(Emory Univ. Atlanta, GA, United States)
Honeycutt, C.
(Emory University Atlanta, GA, United States)
Date Acquired
August 11, 2013
Publication Date
December 1, 1982
Subject Category
Life Sciences (General)
Accession Number
83A27800
Funding Number(s)
CONTRACT_GRANT: NAG2-87
Distribution Limits
Public
Copyright
Other

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