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Fluid shifts and erythropoiesis - Relevance to the 'anemia' of space flightTo model the fluid shifts thought to occur in man during space flight, cephalic fluid shifts have been induced in man subjected to horizontal or headdown bedrest, in squirrel monkeys exposed to lower body positive pressure, and in rats subjected to antiorthostatic hypokinesia. The influence on erythropoiesis of such fluid redistribution has been studied. Only in man did a cephalic fluid shift consistently and significantly lead to a plasma volume reduction and an increased hematocrit. Although there was evidence for erythrosuppression and the subjects were 'anemic' at the end of the study, serum erythropoietin titers remained normal throughout bedrest. The erythrosuppression probably did not arise due to the increased hematocrit but may have been related to P50 shifts or the loss of body weight. Each model appeared to reproduce different parts of man's physiological response to weightlessness and promises to be useful in unraveling the etiology of the 'anemia' of space flight.
Document ID
19830046583
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Dunn, C. D. R.
(Northrop Services, Inc.; Baylor University Houston, TX, United States)
Johnson, P. C.
(Northrop Services, Inc. Houston, TX, United States)
Leach, C. S.
(NASA Johnson Space Center Houston, TX, United States)
Date Acquired
August 11, 2013
Publication Date
December 1, 1982
Subject Category
Life Sciences (General)
Accession Number
83A27801
Funding Number(s)
CONTRACT_GRANT: NAGW-308
CONTRACT_GRANT: NAS9-15425
CONTRACT_GRANT: NAS9-16180
CONTRACT_GRANT: NAS9-16154
Distribution Limits
Public
Copyright
Other

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