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Calcium transport from the intestine and into bone in a rat model simulating weightlessnessThe objective of this study was to determine whether a defect in transport of calcium in the duodenum was related to decreased bone formation in the suspended rat. Rats were suspended by the tail at a 40 deg angle for up to 15 days. Ca-45 was injected into the ligated duodenum in situ 15 minutes prior to sacrific. Blood, tibia, vertebra and humerus were obtained for total calcium and Ca-45 analyses. Intestinal calcium transport did not appear to be significantly altered by suspension. However, by 5 days of suspension a significant decrease in accumulation of Ca-45 into tibia and vertebra was observed. A trend of decreasing bone mineral and mass was established in tibia and vertebra by the fifth day of suspension. The humerus failed to demonstrate a significant weight decrease or change in Ca-45 accumulation after 15 days of suspension. Results from this simulated weightlessness model suggest that transport of calcium from intestine into bone is decreased within 5 days of suspension. This deficiency appears to be associated with a progressive decrease in total mass of non-weightbearing bones.
Document ID
19830046614
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Bikle, D. D.
(NASA Ames Research Center Moffett Field, CA, United States)
Globus, R. K.
(U.S. Veterans Administration, Medical Center San Francisco, CA, United States)
Morey, E. R.
(NASA Ames Research Center Moffett Field, CA, United States)
Date Acquired
August 11, 2013
Publication Date
December 1, 1982
Subject Category
Life Sciences (General)
Accession Number
83A27832
Distribution Limits
Public
Copyright
Other

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