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Is suppression of bone formation during simulated weightlessness related to glucocorticoid levelsTo investigate the hypothesis that suppression of bone formation in the suspended rat model was the result of increased levels of corticosterone, experiments were performed on young, growing, male rats exposed either to 4 C or suspended for two weeks. Rats suspended on the model system, designed to simulate certain aspects of spaceflight, gained weight at a rate at least equal to control animals but still showed a significant suppression of bone formation within 7 days. Cold-exposed rats gained less weight than their corresponding control group and did not demonstrate any suppression of bone formation. These findings suggest: (1) tail suspension is less stressful than previously used harness systems; (2) suspension in young, rapidly growing rats causes a significant suppression of cortical bone formation; (3) cold exposure does not alter bone formation rate in rats of a similar age and strain to those suspended in this study; and (4) suppression of bone formation provoked by unloading the rear limbs is not due solely to sustained stimulation of the pituitary-adrenal system.
Document ID
19830046615
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Morey-Holton, E. R.
(NASA Ames Research Center Moffett Field, CA, United States)
Bomalaski, M. D.
(NASA Ames Research Center Moffett Field, CA, United States)
Enayati-Gordon, E.
(NASA Ames Research Center Moffett Field, CA, United States)
Gonsalves, M. R.
(NASA Ames Research Center Moffett Field, CA, United States)
Wronski, T. J.
(NASA Ames Research Center Biomedical Research Div., Moffett Field, CA, United States)
Date Acquired
August 11, 2013
Publication Date
December 1, 1982
Subject Category
Life Sciences (General)
Accession Number
83A27833
Distribution Limits
Public
Copyright
Other

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