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Effect of suspension hypokinesia/hypodynamia on glucocorticoid receptor levels in rat hindlimb musclesIlyina-Kakueva et. al. (1976) conducted an investigation in which rats were exposed to weightlessness during the Cosmos program. An examination of the rats revealed a marked atrophy of hindlimb muscles. A suspension model has been developed to simulate these weightlessness-induced alterations. In agreement with the Cosmos studies, suspension hypokinesia/hypodynamia (H/H) results in differential atrophy of hindlimb muscles in rats. Recent studies have demonstrated elevated glucocorticoid receptor numbers in the gastrocnemius muscle following immobilization and denervation. One of the objectives of the present investigation was to evaluate the effect of suspension H/H on glucocorticoid receptor levels in rat hindlimb muscles. Another objective was to ascertain whether altered receptor levels reflect the differential nature of hindlimb muscle atrophy during suspension H/H. The obtained findings suggest that differential muscle atrophy resulting from H/H may result from differential alterations of glucocorticoid receptor levels.
Document ID
19830046618
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Steffen, J. M.
(Louisville Univ. KY, United States)
Musacchia, X. J.
(Louisville, University Louisville, KY, United States)
Date Acquired
August 11, 2013
Publication Date
December 1, 1982
Subject Category
Life Sciences (General)
Accession Number
83A27836
Funding Number(s)
CONTRACT_GRANT: NSG-2325
CONTRACT_GRANT: NAGW-70
Distribution Limits
Public
Copyright
Other

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