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Prostacyclin-induced hyperthermia - Implication of a protein mediatorThe mechanism of the prostacyclin-linked hyperthermia is studied in rabbits. Results show that intracerebroventricular administration of prostacyclin (PGI2) induces dose-related hyperthermia at room temperature (21 C), as well as at low (4 C) and high (30 C) ambient temperatures. It is found that this PGI2-induced hyperthermia is not mediated by its stable metabolite 6-keto prostaglandin F-1(alpha). Only one of the three anion transport systems, the liver transport system, appears to be important to the central inactivation of pyrogen, prostaglandin E2, and PGI2. Phenoxybenzamine and pimozide have no thermolytic effect on PGI2-induced hyperthermia, while PGI2 still induces hyperthermia after norepinephrine (NE) and dopamine levels are depleted by 6-hydroxydopamine. Indomethacin and SC-19220 (a PG antagonist) do not antagonize PGI2 induced hyperthermia, while theophylline does not accentuate the PGI2-induced hyperthermia. However, the hyperthermic response to PGI2 is attenuated by central administration of the protein synthesis inhibitor, anisomycin. It is concluded that PGI2-induced hyperthermia is not induced by NE, dopamine, or cyclic AMP, but rather that a protein mediator is implicated in the induction of fever by PG12.
Document ID
19830047538
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Kandasamy, S. B.
(NASA Ames Research Center Moffett Field, CA, United States)
Williams, B. A.
(NASA Ames Research Center Biosystems Div., Moffett Field, CA, United States)
Date Acquired
August 11, 2013
Publication Date
January 1, 1982
Publication Information
Publication: Neuropharmacology
Volume: 21
Subject Category
Life Sciences (General)
Accession Number
83A28756
Distribution Limits
Public
Copyright
Other

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