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Effect of denervation and reinnervation on oxidation of 6-(C-14) glucose by rat skeletal muscle homogenatesThe effects of denervation and reinnervation of the rat extensor digitorum longus muscle on the oxidation of 6-(C-14) glucose to (C-14)O2 is investigated. Results show that the rate of (C-14)O2 production decreased dramatically following denervation and the decrease became significant 20 days after nerve section. The changes which occurred prior to day 20 apparently reflected the decline of muscle mass. The decreased (C-14)O2 production was found to be due to reduced capacity of the enzymatic system, while there was no change in the apparent affinity for glucose. Results of mixing experiments showed that the loss of oxidative capacity following denervation is not caused by the production of soluble inhibitors by degenerating muscle. Measurements of the (C-14)O2 revealed that oxidative metabolism recovered during reinnervation. The specific activity in reinnervated muscles displayed an 'overshoot' of approximately 50 percent, which returned to control levels by day 60. The time-course of the denervation-mediated change indicates that altered oxidative capacity is secondary to events that initiate dennervation changes in muscle, although diminished oxidative capacity may be of considerable metabolic significance in denervated muscle.
Document ID
19830048333
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Dubois, D. C.
(Maryland Univ. Baltimore, MD, United States)
Max, S. R.
(Maryland, University Baltimore, MD, United States)
Date Acquired
August 11, 2013
Publication Date
January 1, 1983
Publication Information
Publication: Journal of Neurochemistry
Volume: 40
Issue: 3 19
ISSN: 0022-3042
Subject Category
Life Sciences (General)
Accession Number
83A29551
Funding Number(s)
CONTRACT_GRANT: NIH-NS-15760
CONTRACT_GRANT: NAG2-100
Distribution Limits
Public
Copyright
Other

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